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Choline is an essential nutrient which is absorbed in the upper small intestine by specific enterocyte transporters via facilitated (Radziejewska and Chmurzynska, 2019), only excessive amounts are metabolized into TMA by the gut microbiota in the colon (Papandreou et al., 2020)

5.4 Use in Women of Childbearing Potential Because of the risk to the fetus of decreased IQ, neurodevelopmental disorders, and major congenital malformations (including neural tube defects), which may occur very early in pregnancy, valproate should not be administered to a woman of childbearing potential unless other medications have failed to provide adequate symptom control or are otherwise unacceptable

151 Although these studies demonstrated a beneficial effect of the KD on PCOS, they have limitations such as small sample size, broad age range, single-arm design, and a short intervention time interval

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A 2024 study in the British Journal of Dermatology demonstrated that skin barrier dysfunction activates the NLRC4 inflammasome, creating a vicious cycle of inflammation that makes the skin highly reactive, sensitive, and prone to chronic rashes or severe acne breakouts